PawPrint Protocol vs Leap Years: Which Dog NAD+ Wins?

Both of these promise the same thing, more pep in an aging dog by topping up the NAD+ that fades with age, but they hand it to your dog in two very different ways. A PawPrint Protocol vs Leap Years choice really comes down to a dropper you add to dinner against a chew backed by a study.

The PawPrint Protocol is a daily liquid NAD+ supplement for dogs, a four-in-one blend you dose onto food. Leap Years is a soft chew from Animal Biosciences that combines an NAD+ booster with a senolytic to clear out worn cells.

We read both makers’ ingredient lists and dosing, checked the price and guarantee on each, and set the science side by side, including the one published dog trial in the category. One wins on proof. The other wins on price and on the simple fact that a fussy dog will actually take it. Here’s the split.

PawPrint Protocol vs Leap Years at a glance

Same goal, two different formats

Start with the common ground, because it’s real. Both are healthy-aging supplements built around NAD+, the coenzyme that powers how cells make energy and that drops as a dog gets older. Both are daily habits aimed at vitality over weeks, not overnight fixes, and neither is a medicine.

The PawPrint Protocol is a liquid you add to a meal, with a four-part blend of NMN, NAD+, resveratrol and CoQ10. That format is the whole point: a dog that noses a tablet out of the bowl will just eat food with a few drops in it.

Leap Years takes the chew route. It pairs an NAD+ booster with a senolytic that helps clear senescent cells, and it comes from Animal Biosciences, the company co-founded by Harvard geneticist David Sinclair. It’s the one brand in the category with a published trial, which matters, and we’ll give it full credit for that below.

Round by round

Price

Round winner: PawPrint Protocol

Give this one to PawPrint. A single bottle runs about $69 and drops to roughly $52 a month on Subscribe & Save, and that’s a month’s supply for a mid-size dog.

Leap Years lands near $100 for a one-month supply, so it’s close to double the monthly cost. If you’re committing to a daily supplement for the long haul, that gap adds up fast, and the PawPrint is the friendlier line on the budget.

Format and daily use

Round winner: PawPrint Protocol

This is where the PawPrint earns its case. The liquid dropper solves the single biggest reason supplement routines fail: a dog that won’t take it. You match the dose to your dog’s weight, add it to dinner, and you’re done, no hiding a pill in cheese.

Leap Years is a soft chew, which plenty of dogs happily eat. But a fussy eater or a dog that clamps its jaw at a gummy is exactly the dog this round is about, and the drop-it-in-food format wins for the widest range of dogs.

Evidence

Round winner: Leap Years

Here’s the honest one, and it goes to Leap Years. It’s the only brand here with a published, placebo-controlled dog trial. In its 2024 study of senior dogs, owner-rated cognition improved or stayed stable in 89% of the full-dose group versus 60% on placebo.

Read that fairly in both directions. It’s genuine, category-leading evidence, and independent skeptics also note it leans on owner-reported scores from a company-run study. PawPrint’s individual ingredients are studied, but its finished formula hasn’t had its own trial, so on proof, Leap Years clearly takes the round.

Formula and antioxidants

Round result: Tie

Call this a wash, because they’re built on the same idea from different angles. The PawPrint stacks four actives, NMN and NAD+ plus resveratrol and CoQ10, so it bundles cellular-energy support with two antioxidants in one drop.

Leap Years goes narrower and deliberate: an NAD+ booster plus a senolytic to clear senescent cells, which is a mechanism PawPrint doesn’t target. One is broader, one is more focused. Which theory you prefer is genuinely personal, so this round is even.

Guarantee

Round winner: PawPrint Protocol

The PawPrint backs its bottle with a 90-day money-back guarantee, a long runway to judge a supplement that works over weeks. One bit of fine print: the clock starts at delivery, so mark your calendar from the day it lands.

Leap Years offers a shorter 30-day money-back window. For a product you’re meant to give daily for a month or more before judging, the longer guarantee is the one that actually lets you find out, so PawPrint takes it.

The honest scorecard

Who should buy which

Choose the PawPrint Protocol if you want the easier daily habit: a food-friendly NAD+ drop a picky dog will actually take, a four-part blend, and a 90-day guarantee, all for roughly half of what Leap Years costs a month. For most owners, that’s the practical win.

Choose Leap Years if published proof is your deciding factor and your dog happily eats chews. It’s the brand with the trial behind it, and that’s a fair reason to pay more.

Either way, keep it realistic and loop in your vet: these support healthy aging, they don’t treat disease, and results vary by dog. For the full breakdown on our pick, read the PawPrint Protocol review, see where it lands in our best NAD+ supplement for dogs roundup, and for stiff senior hips our best joint supplements of 2026 guide helps. There’s more in the health hub.

Check today's PawPrint Protocol price